Collagen type I alpha 1 gene polymorphism in premature ovarian failure
Introduction.Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogenism in women bellow 40 years.Osteoporosis is one of the late complications of POF.Objective.To correlate collagen type I alpha1 (COLIA1) gene polymorphism with bone mineral density (BMD) in women with POF.Methods.We determined the COLIA1